HCID 44625647, compound → HCID 66633827, compound

HRID 1925173Notes

Reaction equation

HRID 1925173 reaction equation
CN1C=C([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([S:16][C:17]4[CH:18]=[CH:19][C:20]5[N:21]([CH:23]=[C:24]([NH:26][C:27]([CH:29]6[CH2:31][CH2:30]6)=[O:28])[N:25]=5)[N:22]=4)=[N:14][N:15]=3)[CH:12]=2)C=N1.[C:32]([C:34]1[CH:35]=[C:36](B(O)O)[CH:37]=[N:38][C:39]=1[O:40][CH2:41][O:42][CH2:43][CH2:44][Si:45]([CH3:48])([CH3:47])[CH3:46])#[N:33]>>[C:32]([C:34]1[CH:35]=[C:36]([C:7]2[CH:8]=[CH:9][C:10]3[N:11]([C:13]([S:16][C:17]4[CH:18]=[CH:19][C:20]5[N:21]([CH:23]=[C:24]([NH:26][C:27]([CH:29]6[CH2:30][CH2:31]6)=[O:28])[N:25]=5)[N:22]=4)=[N:14][N:15]=3)[CH:12]=2)[CH:37]=[N:38][C:39]=1[O:40][CH2:41][O:42][CH2:43][CH2:44][Si:45]([CH3:48])([CH3:47])[CH3:46])#[N:33]

Participants

3

Reactant 2

HCID 44625647HCID 44625647, compoundHCID 66631864HCID 66631864, compound

Product 1

HCID 66633827HCID 66633827, compound

Procedure

The title compound was synthesized using an analogous procedure to that described in the preparation of Compound 5 using 5-cyano-6-((2-(trimethylsilyl)ethoxy)methoxy)pyridin-3-ylboronic acid. The crude reaction was used for the next step without further purification.

Workup

  1. customThe crude reaction
  2. customwas used for the next step without further purification

Sources & evidence

ORD record
ord-468db5ced4a845cdb321edf1b60c4ab4
Source dataset
uspto-grants-2012_05
Patent number
US08178534B2

Reaction notes

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