反应详情

The title compound was prepared from N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide and 6-((2-methoxyethoxy)methyl)-[1,2,4]triazolo[4,3-a]pyridine-3-thiol following the procedure described for the synthesis of Compound 4. 1H NMR (METHANOL-d4, 400 MHz): δ=8.75-8.78 (m, 1H), 8.15 (dd, J=9.3, 1.0 Hz, 1 H), 8.04-8.11 (m, 1 H), 8.02 (d, J=9.3 Hz, 1 H), 7.94 (s, 1 H), 7.56 (d, J=9.3 Hz, 1 H), 4.71 (d, J=1.0 Hz, 2 H), 3.61-3.67 (m, 2 H), 3.47-3.53 (m, 2 H), 3.29 (s, 3 H), 1.80-1.87 (m, 1 H), 0.88-1.01 ppm (m, 4 H). ESI-MS:m/z 440.2 (M+H)+.