N-(6-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide → tert-Butyl 6-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-ylcarbamate

HRID 1925180Notes

Reaction equation

HRID 1925180 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[N:10]=2)[N:7]=1.[N:19]1[N:20]=[C:21]([SH:28])[N:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=12.BrC1C=CC2N(C(SC3C=CC4N(C=C(NC(C5CC5)=O)N=4)N=3)=NN=2)C=1>>[N:19]1[N:20]=[C:21]([S:28][C:2]2[CH:3]=[CH:4][C:5]3[N:6]([CH:8]=[C:9]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[N:10]=3)[N:7]=2)[N:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=12

Participants

4

Reactant 3

HCID 46174984N-(6-(6-bromo-[1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamideHCID 46941915Tert-butyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamateHCID 178527925HCID 178527925, compound

Product 1

HCID 66634119tert-Butyl 6-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-ylcarbamate

Procedure

The title compound was prepared from tert-butyl 6-iodoimidazo[1,2-b]pyridazin-2-ylcarbamate and [1,2,4]triazolo[4,3-a]pyridine-3-thiol following the procedure for the synthesis of compound 4.

Sources & evidence

ORD record
ord-6461b2798bae46a291544a7fa3bf3ea2
Source dataset
uspto-grants-2012_05
Patent number
US08178534B2

Reaction notes

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