反应详情

A solution of tert-butyl 6-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-ylcarbamate (300 mg, 0.78 mmol) in dioxane (5 ml) was treated with 4M HCl in dioxane (5 ml) at 80° C. for 1 hr. The mixture was concentrated and purified by LCMS to give the title compound, 6-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-amine (201 mg, 68% yield) as the TFA salt. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.00 (d, J=9.35 Hz, 1 H) 7.16 (t, J=6.44 Hz, 1 H) 7.22 (s, 1 H) 7.54-7.65 (m, 1 H) 7.73 (d, J=9.35 Hz, 1 H) 8.00 (d, J=9.09 Hz, 1 H) 8.47 (d, J=6.82 Hz, 1 H). ESI-MS:m/z 284.2 (M+H)+.

1. concentrationThe mixture was concentrated
2. custompurified by LCMS