L-Isoleucine → HCID 67520545, compound

Participants

Reaction Conditions

Reaction Steps

A 300 ml round-bottomed flask equipped with a Dimroth condenser was charged with 13.13 g (100 mmol) of L-isoleucine and 1000 ml of tetrahydrofuran. After the addition of 30.4 g (100 mmol) of bis(4-nitrophenyl) carbonate, the mixture was stirred at 60° C. for 20 hours. After evaporating the solvent, the residue was purified by column chromatography to obtain 8.3 g of N-(4-nitrophenoxycarbonyl)-L-isoleucine.

Provenance & Evidence