HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 59397456, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 9H-Fluoren-9-ylmethyl 12,12-dimethyl-10-oxo-5,8,11-trioxa-2-azatridecanoate | HCID 67519510 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59397456 | HCID 59397456 | — |
Reaction Steps
100 mg (0.226 mmol) of 8-(9-Fluorenylmethoxycarbonylamino)-3,6-dioxaoctanoic acid tert-butylester in 1 mL of dry DMF were treated with piperidine (89.5 μL; 0.862 mmol) at r.t. for 3 hours. The solvent was evaporated and the residue purified by chromatography on silica gel with a gradient cHex→EtOAc→EtOAc MeOH (1:1)+3% MeOH. Yield: 12 mg (24%) of the title compound. ESI MS: 220.08 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178650B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-537ba94f44664a8b8d2be8a39166636e |
| Source note | uspto-grants-2012_05 |