HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1925209Generated: October 28, 2026
Diisopropylethylamine → HCID 178479479, compound
https://huagongshe.com/reaction/1925209
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (3R)-1-Azabicyclo(2.2.2)octan-3-amine | HCID 719215 | — |
| Reactant | HCID 178479321 | HCID 178479321 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178479479 | HCID 178479479 | — |
Reaction Steps
To a mixture of (R)-3-aminoquinuclidine (5.85 g, 46.4 mmol) and pyrazole carbox-amidine hydrochloride (6.80 g, 46.4 mmol) is added Hunig's base (8.07 ml, 46.4 mmol) and DMF (30 ml). The reaction is heated at 70° C. for 40 hours. The reaction is then cooled to room temperature and quenched by adding 400 ml of diethyl ether and stirring at room temperature for 2 hours. Product separates out as a white solid, which is filtered, washed and dried (8.94 g, 94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08178672B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-865146a99db44bbb99d0205283fc3df0 |
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| Source note | uspto-grants-2012_05 |
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