Hydrochloric Acid → HCID 67519857, compound

Participants

Reaction Steps

The tert-butyl 4-({4-[6-(2-chlorophenyl)imidazo[2,1-b][1,3]oxazol-5-yl]pyrimidin-2-yl}amino)piperidine-1-carboxylate (1.8 g, 3.6 mmol) is dissolved in 20 ml of dioxane and treated with 40 ml of anhydrous a four molar HCl in dioxane at room temperature (RT). The reaction mixture is stirred at room temperature for three hours. The mixture is then diluted with 100 ml of ether and stirred until product separates as a solid. Solid product is filtered and washed with ether. The product is dried at high vacuum to yield 1.3 g of pale yellow solid (94%).

Provenance & Evidence