Hydrochloric Acid → Ziprasidone Hydrochloride

Participants

Reaction Conditions

Reaction Steps

To substantially pure ziprasidone base (100 g), was added dichloromethane (2.0 Lit) and stirred for 15-20 minutes at 30-35° C. To this, ethereal solution of hydrogen chloride (95.7 ml) was added over a period of 5-10 min at 30-35° C. under stirring. The suspension was further stirred for 17-20 hours at 32-35° C. and separated solids were filtered under vacuum and nitrogen atmosphere at 32-35° C. The wet solid was washed with diethyl ether (100 ml). The wet cake so obtained was suspended in acetone (500 ml) at 30-35° C. and stirred for 15-20 minutes at 30-35° C. The solid was filtered, washed with acetone (0.20 Lit) and dried under vacuum at 55-60° C. for 12-15 hours till the moisture content was not more than 0.5% w/w.

Provenance & Evidence