Hydrochloric Acid → HCID 16662683, compound

Participants

Reaction Steps

To a stirred solution of Ethyl 3-(3-(2,6-dimethylbenzyloxy)phenyl)-2-methylpropanoate (Step C, 1.61 g, 4.9 mmol) in absolute ethanol (25 ml) was added 1N NaOH (10 ml) at room temperature. The reaction mixture was stirred for 3 hours, acidified to pH 3.5-4.0 by 1N HCl, and concentrated. The residue was taken into chloroform and washed with 0.1N HCl, brine, dried over Na2SO4, filtered, concentrated and purified by flash chromatography on a silica gel column (chloroform:methanol 95:5 spiked with acetic acid) to give the title compound.

Provenance & Evidence