Phenylacetyl chloride → HCID 67520449, compound

HRID 1925252Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([OH:12])[CH:6]=[CH:5]2.[C:13]1([CH2:19][C:20](Cl)=[O:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[OH:12][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[CH:3]=[C:2]([NH:1][C:20](=[O:21])[CH2:19][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:11]=[CH:10]2

Participants

Reactant 2

HCID 7679Phenylacetyl chloride

HCID 4286056-Amino-2-naphthalenol

Product 1

HCID 67520449HCID 67520449, compound

Procedure

The 6-aminonaphthalen-2-ol from Step (a) above (320 mg, 2.0 mmol) reacted with phenylacetyl chloride (683 mg, 4.4 mmol, Aldrich) under the conditions of Example 1d to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 278.3 (M+1). Mass Calc'd for C18H15NO2: 277.11.

Sources & evidence

ORD record: ord-61210ed5362948abba5b8e8e8010b0d4
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08178557B2

Reaction notes

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