4-Chloro-6,7-dimethoxyquinazoline → HCID 59813858, compound

HRID 1925253Notes

Reaction equation

HRID 1925253 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([NH:12][C:13](=[O:21])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH:6]=[CH:5]2.Cl[C:23]1[C:32]2[C:27](=[CH:28][C:29]([O:35][CH3:36])=[C:30]([O:33][CH3:34])[CH:31]=2)[N:26]=[CH:25][N:24]=1>>[CH3:34][O:33][C:30]1[CH:31]=[C:32]2[C:27](=[CH:28][C:29]=1[O:35][CH3:36])[N:26]=[CH:25][N:24]=[C:23]2[O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([NH:12][C:13](=[O:21])[CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 67520449HCID 67520449, compound

Product 1

HCID 59813858HCID 59813858, compound

Procedure

N-(6-Hydroxy-2-naphthyl)-2-phenylacetamide from step (b) above (260 mg, 0.9 mmol) reacted with 4-chloro-6,7-dimethoxy-quinazoline (210 mg, 0.9 mmol, Oakwood) under the conditions of Example 4b to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 466.2 (M+1). Mass Calc'd for C28H23N3O4: 465.17.

Sources & evidence

ORD record
ord-75c75060a9154649b4e6003348b0bfc3
Source dataset
uspto-grants-2012_05
Patent number
US08178557B2

Reaction notes

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