Ethyl isocyanate → HCID 11156826, compound

Participants

Reaction Steps

To a solution of 6-[6-methoxy-7-(3-morpholin-4-ylpropoxy)-4-quinolyloxy]-2-naphthylamine (prepared similar to that described in Example 1, Step c) (46.0 mg, 0.1 mmol) in anhydrous DMF (5 mL, Aldrich) was added Et3N (50.5 mg, 0.5 mmol, Aldrich) and ethyl isocyanate (35.5 mg, 0.5 mmol, Aldrich) at RT. The reaction was stirred at RT for 16 h, then was quenched with saturated aqueous solution of NaHCO3 (20 mL) and extracted with EtOAc (2×30 mL). The combined organic extracts were dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by column chromatography (FPNH-25S, Biotage, EtOAc) to give the title compound as white solid. MS (ESI, pos. ion) m/z: 531.3 (M+1); 529.3 (M−1). Calc'd for C30H33N4O5−530.25.

Provenance & Evidence