HCID 67520578, compound → HCID 67520412, compound

HRID 1925283Notes

Reaction equation

HRID 1925283 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:25]=[C:24]2[C:19]([CH:20]=[CH:21][C:22]([C:26]([O:28]C)=[O:27])=[CH:23]2)=[CH:18][CH:17]=1>CCO.[OH-].[Na+]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:25]=[C:24]2[C:19]([CH:20]=[CH:21][C:22]([C:26]([OH:28])=[O:27])=[CH:23]2)=[CH:18][CH:17]=1

Participants

4

Reactant 1

HCID 67520578HCID 67520578, compound

Product 1

HCID 67520412HCID 67520412, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Conditions

Temperature
70 °C

Procedure

To a solution of methyl 7-(6,7-dimethoxyquinolin-4-yloxy)-2-naphthoate (Step c, 0.809 g, 2.08 mmol) in EtOH (10 mL), 1N NaOH (3 mL) was added. The solution was stirred at 70° C. for 2 h. The reaction was cooled to RT and concentrated in vacuo. The crude material was taken up in water (50 mL) and acidified to pH=3 with 1N HCl. The solid was filtered and dried in vacuo. MS (ESI, pos. ion) m/z: 376.1 (M+1).

Workup

  1. temperatureThe reaction was cooled to RT
  2. concentrationconcentrated in vacuo
  3. filtrationThe solid was filtered
  4. customdried in vacuo

Sources & evidence

ORD record
ord-4be0111dd6944fc29592349ad845ed5b
Source dataset
uspto-grants-2012_05
Patent number
US08178557B2

Reaction notes

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