HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 6-(2-Amino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 6-(2-Fluoropyrimidin-4-yloxy)-1-naphthoic acid | HCID 67520542 | — |
| Product | 6-(2-Amino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid | HCID 57455159 | — |
Reaction Steps
6-(2-Fluoropyrimidin-4-yloxy)-1-naphthoic acid (1.2 g, 4.2 mmol) was dissolved in NH4OH (37% water, 20 mL) and stirred at RT for 3h. Solvent was evaporated. A little bit of MeOH was added to the slurry followed by ether until the compound crashed out. Solid was filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178557B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-756f5f6919d4482c982d9bb85dc6f0a0 |
| Source note | uspto-grants-2012_05 |