Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2,4-Dichloropyridine | HCID 33515 | — |
| Reactant | 6-Hydroxy-1-naphthoic acid | HCID 5463800 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 24823893 | HCID 24823893 | — |
Reaction Steps
6-Hydroxynaphtoic acid (10.0 g, 53.1 mmol), 2,4-dichloropyridine (9.44 g, 63.8 mmol) and cesium carbonate (51.9 g, 159 mmol) were combined in DMSO (266 mL) and the reaction mixture was heated at 90° C. for 16 h. After cooling to RT, water was added and the aqueous layer was acidified to pH=4-5. The title compound was isolated by filtration and dried under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08178557B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-7afbf60b4e3c4907998152ffe6259a85 |
|---|
| Source note | uspto-grants-2012_05 |
|---|
