Methyl iodide → tert-Butyl (1-methyl-6-oxo-1,6-dihydropyridin-3-yl)carbamate

Participants

Reaction Steps

To a stirred solution of tert-butyl 6-methoxypyridin-3-ylcarbamate (14.4 g, 64.2 mmol) in MeOH (95 mL) was added methyl iodide (14.6 g, 103 mmol). The reaction mixture was heated at reflux for 16 h, cooled to RT and concentrated down. The residue was purified by silica gel chromatography to give the title compound.

Provenance & Evidence