HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1925334Generated: October 28, 2026
Hydrochloric Acid → 5-Amino-1-methyl-1,2-dihydropyridin-2-one hydrochloride
https://huagongshe.com/reaction/1925334
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-Butyl (1-methyl-6-oxo-1,6-dihydropyridin-3-yl)carbamate | HCID 15185799 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Amino-1-methyl-1,2-dihydropyridin-2-one hydrochloride | HCID 45791605 | — |
Reaction Steps
To a stirred solution of tert-butyl 1-methyl-6-oxo-1,6-dihydropyridin-3-ylcarbamate (1.20 g, 5.35 mmol) in dioxane (15 mL) at RT was added HCl (4M in dioxane, 5.35 mL, 21.4 mmol). The reaction mixture was heated at 70° C. for 9 h, cooled to RT and filtered to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08178557B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-47c2908b888c4251ad74288607878f95 |
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| Source note | uspto-grants-2012_05 |
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