HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Anisidine → N-(6-((6,7-bis(methoxy)-4-quinolinyl)oxy)-1-naphthalenyl)-N'-(4-(methoxy)phenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | 4-(5-Isothiocyanatonaphthalen-2-yloxy)-6,7-dimethoxyquinoline | HCID 86062314 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(6-((6,7-bis(methoxy)-4-quinolinyl)oxy)-1-naphthalenyl)-N'-(4-(methoxy)phenyl)thiourea | HCID 59813195 | — |
Reaction Steps
To a solution of 4-(5-isothiocyanatonaphthalen-2-yloxy)-6,7-dimethoxyquinoline (27 mg, 0.070 mmol) in DCM (348 μL) at RT was added 4-methoxyaniline (17.2 mg, 0.140 mmol) in one portion. After stirring for 14 h, the crude mixture was concentrated under reduced pressure and purified by silica gel chromatography. MS (ESI, pos. ion) m/z: 512.1. (M+1). Mass Calc'd for C18H15NO3: 511.60.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178557B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-813b94087f064b7abf62e243da2a15fe |
| Source note | uspto-grants-2012_05 |