HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrophenyl chloroformate → 4-Nitrophenyl isoxazol-3-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | 3-Isoxazolamine | HCID 1810216 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Nitrophenyl isoxazol-3-ylcarbamate | HCID 67519991 | — |
Reaction Steps
A solution of 3-amino isoxazole (220 uL, 2.973 mmol) and p-nitrophenyl chloroformate (659 mg, 3.271 mmol) in THF (8 mL) was stirred for 15 min at RT before the solution was concentrated in vacuo. The title compound was used immediately in the following reaction without further purification. MS (ESI, pos. ion) m/z: 250 (M+1). Mass calc'd for C10H7N3O5: 249.18.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178557B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-c5c55cf3f6274bd5a45bc7b3e61f7bce |
| Source note | uspto-grants-2012_05 |