Sodium Hydroxide → HCID 67519859, compound

HRID 1925371Notes

Reaction equation

HRID 1925371 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[NH:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[C:22]([C:26]([O:28]C)=[O:27])=[CH:21][CH:20]=[CH:19]2.[OH-].[Na+]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[NH:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[C:22]([C:26]([OH:28])=[O:27])=[CH:21][CH:20]=[CH:19]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67520244HCID 67520244, compound

Product 1

HCID 67519859HCID 67519859, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 6-(6,7-dimethoxyquinazolin-4-ylamino)-1-naphthoate (500 mg, 1.28 mmol) was stirred with 6N NaOH (10 mL) and MeOH (10 mL) at 70° C. for 3 h. The mixture was poured into 6N HCl/ice and the pH adjusted to 7. The solid was collected and rinsed with water, stirred with MeOH (5 mL) and filtered again. The title compound was obtained (crude) as a yellow solid.

Workup

  1. customThe solid was collected
  2. washrinsed with water
  3. filtrationfiltered again

Sources & evidence

ORD record
ord-2b80316acd0d4c539959737e514ebf7d
Source dataset
uspto-grants-2012_05
Patent number
US08178557B2

Reaction notes

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