反应详情

Into a 100 mL round bottom flask was placed LAH (1.518 g, 40 mmol) and suspended in THF (30 mL). Flask placed into an ice bath. Tert-butyl 4-(3-amino-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate (1.368 g, 4 mmol) is added to THF (10 mL) and this solution is in turn added dropwise to the LAH suspension at 0° C. 15 min after addition was complete, flask is equipped with reflux condensor and allowed to reflux 15 h with stirring. Work up: Water (1.5 g) is added dropwise, then 15% NaOH(aq)(w/w)(1.5 g), followed by water (3 g). White precipitate forms after 20 h of stirring, filtered solids, removed solvent under reduced pressure. No further purification done. LC-MS (+) shows mass 257 (M+H), as expected for C13H15F3N2, mw 256.27.

1. customInto a 100 mL round bottom flask was placed
2. customFlask placed into an ice bath
3. addition15 min after addition
4. customflask is equipped
5. temperaturewith reflux condensor
6. temperatureto reflux 15 h
7. stirringWhite precipitate forms after 20 h of stirring
8. filtrationfiltered solids
9. customremoved solvent under reduced pressure
10. customNo further purification