Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N,N-dimethyl-5-nitropyridin-2-amine | HCID 75707 | — |
Reaction Steps
2-Chloro-5-nitropyridine (3.57 g, 22.5 mmol), dimethylamine hydrochloride (5.50 g, 67.5 mmol) and diisopropylethylamine (13.7 mL, 78.7 mmol) were combined in DMSO (15 mL) and the reaction mixture was heated at 80° C. for 4 h. After cooling to RT, water was added and the desired N,N-dimethyl-5-nitropyridin-2-amine was isolated by filtration and used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08178557B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-da03610e674b4bfe897afbabd2297416 |
|---|
| Source note | uspto-grants-2012_05 |
|---|
