HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3-Dimethyl-1-[2-nitro-4-(trifluoromethyl)phenyl]azetidin-2-one → 1-[2-Amino-4-(trifluoromethyl)phenyl]-3,3-dimethyl-2-azetidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3-Dimethyl-1-[2-nitro-4-(trifluoromethyl)phenyl]azetidin-2-one | HCID 26985628 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[2-Amino-4-(trifluoromethyl)phenyl]-3,3-dimethyl-2-azetidinone | HCID 16086098 | — |
Reaction Steps
A mixture of 3,3-dimethyl-1-(2-nitro-4-(trifluoromethyl)phenyl)azetidin-2-one (1.67 g, 5.8 mmol, 1.0 equiv) and 10% Pd/C (300 mg) in MeOH (30 mL) was exposed to an atmosphere of H2. After consumption of the starting material, the mixture was filtered and concentrated to afford 1-(2-amino-4-(trifluoromethyl)phenyl-3,3-dimethylazetidin-2-one, which was advanced without further purification. MS (MH+) 259.1; Calculated 259.1 for C12H14F3N2O.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178557B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-c10628cf40484a0eb208125c48e93022 |
| Source note | uspto-grants-2012_05 |