4,6-Dichloropyrimidine → HCID 24902132, compound

HRID 1925422Notes

Reaction equation

HRID 1925422 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[F:9][C:10]([F:22])([F:21])[O:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>[Pd]>[Cl:1][C:2]1[CH:7]=[C:6]([C:15]2[CH:14]=[CH:13][C:12]([O:11][C:10]([F:9])([F:21])[F:22])=[CH:17][CH:16]=2)[N:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 709434,6-DichloropyrimidineHCID 27343864-(Trifluoromethoxy)phenylboronic acid

Product 1

HCID 24902132HCID 24902132, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

4-Chloro-6-(4-trifluoromethoxy-phenyl)-pyrimidine was prepared by palladium-catalyzed arylation of 4,6-dichloropyrimidine and 4-trifluoromethoxyphenyl boronic acid. 1H NMR (400 MHz, CDCl3) δ 9.05 (s, 1H), 8.14 (d, J=9.8 Hz, 2H), 7.74 (m, 1H), 7.36 (d, J=8.4 Hz, 2H); EIMS 274 m/z (M+).

Sources & evidence

ORD record
ord-1c973f86aa5b41e2b1ddd785edcdb8f2
Source dataset
uspto-grants-2012_05
Patent number
US08178658B2

Reaction notes

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