Benzyl Bromide → HCID 24721025, compound

Participants

Reaction Steps

To a solution of Intermediate 1 (23.68 g, 0.13 mol) in dimethylformamide (175 mL) was slowly added sodium hydride (60%, 5.29 g, 0.13 mol). The mixture was stirred at room temperature for 1 hour. Then benzyl bromide (15.72 mL, 0.13 mol) was added into the mixture and was stirred at room temperature for 24 hours. The solvent was removed under reduced pressure. The title compound was obtained (26.46 g, 74%) and was used in the next step without further purification. MS (M+): 270.

Provenance & Evidence