HCID 67520510, compound → HCID 42623779, compound

HRID 1925497Notes

Reaction equation

HRID 1925497 reaction equation
[C:1]12([CH2:11][CH2:12][O:13][C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][CH2:23][C@@H:24]([C:26]4[CH:35]=[CH:34][C:33]([O:36]CC5C=CC=CC=5)=[C:32]5[C:27]=4[CH:28]=[CH:29][C:30](=[O:44])[NH:31]5)[OH:25])=[CH:16][CH:15]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>[Pd]>[C:1]12([CH2:11][CH2:12][O:13][C:14]3[CH:15]=[CH:16][C:17]([CH2:20][CH2:21][NH:22][CH2:23][C@@H:24]([C:26]4[CH:35]=[CH:34][C:33]([OH:36])=[C:32]5[C:27]=4[CH:28]=[CH:29][C:30](=[O:44])[NH:31]5)[OH:25])=[CH:18][CH:19]=3)[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

Participants

3

Reactant 1

HCID 67520510HCID 67520510, compound

Product 1

HCID 42623779HCID 42623779, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Obtained from Intermediate 24 (0.1 g, 0.17 mmol) and palladium on charcoal (10%, 0.02 g) by the same procedure described in Example 1 (reaction time: overnight). The crude obtained was triturated with ether giving the title compound as a white solid (0.081 g, 95%).

Workup

  1. customdescribed in Example 1 (reaction time: overnight)
  2. customThe crude obtained
  3. customwas triturated with ether giving the title compound as a white solid (0.081 g, 95%)

Sources & evidence

ORD record
ord-992fcc2379314d249b72ab7471523069
Source dataset
uspto-grants-2012_05
Patent number
US08178679B2

Reaction notes

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