HRID1925504

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=c1ccc2c([C@@H](O)CNCCc3cccc(OCCC45CC6CC(CC(C6)C4)C5)c3)ccc(OCc3ccccc3)c2[nH]1

HCID67520637

未命名化合物

PRODUCTS

生成物

结构：O=c1ccc2c([C@@H](O)CNCCc3cccc(OCCC45CC6CC(CC(C6)C4)C5)c3)ccc(O)c2[nH]1

HCID42623780

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

PROCEDURE

实验过程

Obtained from Intermediate 33 (0.365 g, 0.62 mmol) and palladium on charcoal (10%, 0.075 g) by the same procedure described in Example 1 (reaction time: 20 hours). The crude was purified by column chromatography with silica gel, eluting with methylen chloride/methanol/ammonium (40:2.5:0.1) and the title compound was obtained as a solid (0.113 g, 65%).

WORKUP

后处理

customdescribed in Example 1 (reaction time: 20 hours)
customThe crude was purified by column chromatography with silica gel
washeluting with methylen chloride/methanol/ammonium (40:2.5:0.1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fa7e09a429a540f7a93a6de757743e4d
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08178679B2
来源说明: uspto-grants-2012_05

反应 SMILES

[C:1]12([CH2:11][CH2:12][O:13][C:14]3[CH:15]=[C:16]([CH2:20][CH2:21][NH:22][CH2:23][C@@H:24]([C:26]4[CH:35]=[CH:34][C:33]([O:36]CC5C=CC=CC=5)=[C:32]5[C:27]=4[CH:28]=[CH:29][C:30](=[O:44])[NH:31]5)[OH:25])[CH:17]=[CH:18][CH:19]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>[Pd]>[C:1]12([CH2:11][CH2:12][O:13][C:14]3[CH:15]=[C:16]([CH2:20][CH2:21][NH:22][CH2:23][C@@H:24]([C:26]4[CH:35]=[CH:34][C:33]([OH:36])=[C:32]5[C:27]=4[CH:28]=[CH:29][C:30](=[O:44])[NH:31]5)[OH:25])[CH:17]=[CH:18][CH:19]=3)[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2