HCID 86649164, compound → HCID 59624926, compound

HRID 1925516Notes

Reaction equation

HRID 1925516 reaction equation
[C:1]12([CH2:11][CH2:12][O:13][C:14]3[CH:15]=[C:16]([CH2:20][CH2:21][NH:22][CH2:23][C@@H:24]([C:26]4[CH:27]=[CH:28][C:29]([O:35]CC5C=CC=CC=5)=[C:30]([NH:32][CH:33]=[O:34])[CH:31]=4)[OH:25])[CH:17]=[CH:18][CH:19]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>[Pd]>[C:1]12([CH2:11][CH2:12][O:13][C:14]3[CH:15]=[C:16]([CH2:20][CH2:21][NH:22][CH2:23][C@@H:24]([C:26]4[CH:27]=[CH:28][C:29]([OH:35])=[C:30]([NH:32][CH:33]=[O:34])[CH:31]=4)[OH:25])[CH:17]=[CH:18][CH:19]=3)[CH2:8][CH:7]3[CH2:9][CH:3]([CH2:4][CH:5]([CH2:6]3)[CH2:10]1)[CH2:2]2

Participants

3

Reactant 1

HCID 86649164HCID 86649164, compound

Product 1

HCID 59624926HCID 59624926, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Obtained from Intermediate 61 (0.8 g, 1.41 mmol) and palladium on charcoal (10%, 0.15 g) by the same procedure described in Example 1 (reaction time: 3 hours). The crude was purified by column chromatography with silica gel, eluting with methylen chloride/methanol (from 98:2 to 9:1) and the title compound was obtained as a solid (0.32 g, 47%).

Workup

  1. customdescribed in Example 1 (reaction time: 3 hours)
  2. customThe crude was purified by column chromatography with silica gel
  3. washeluting with methylen chloride/methanol (from 98:2 to 9:1)

Sources & evidence

ORD record
ord-bd838db08d82407585aff74a6892d92d
Source dataset
uspto-grants-2012_05
Patent number
US08178679B2

Reaction notes

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