HCID 67520420, compound → HCID 42623857, compound

HRID 1925523Notes

Reaction equation

HRID 1925523 reaction equation
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][CH2:23][C@@H:24]([C:26]3[CH:35]=[CH:34][C:33]([O:36]CC4C=CC=CC=4)=[C:32]4[C:27]=3[CH:28]=[CH:29][C:30](=[O:44])[NH:31]4)[OH:25])=[CH:16][CH:15]=1)[CH2:8]2>[Pd]>[CH:1]12[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH:2]1[CH2:11][CH2:12][O:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:20][CH2:21][NH:22][CH2:23][C@@H:24]([C:26]3[CH:35]=[CH:34][C:33]([OH:36])=[C:32]4[C:27]=3[CH:28]=[CH:29][C:30](=[O:44])[NH:31]4)[OH:25])=[CH:18][CH:19]=1)[CH2:10]2

Participants

3

Reactant 1

HCID 67520420HCID 67520420, compound

Product 1

HCID 42623857HCID 42623857, compoundYield 52.4%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Obtained from Intermediate 78 (0.33 g, 0.57 mmol) and palladium on charcoal (34 mg, 0.32 mmol) by the same procedure described in Example 1. The crude was purified by column chromatograpy with silica gel, eluting with methylen chloride/methanol (from 20:1 to 10:1) obtaining the title compound as a white solid (0.15 g, 52%).

Workup

  1. customThe crude was purified by column chromatograpy with silica gel
  2. washeluting with methylen chloride/methanol (from 20:1 to 10:1)

Sources & evidence

ORD record
ord-5178b12ae2db41e4b9fead7e7863fdd8
Source dataset
uspto-grants-2012_05
Patent number
US08178679B2

Reaction notes

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