Tetrabutylammonium Fluoride Trihydrate → HCID 67520022, compound

Participants

Reaction Steps

928 mg (1.26 mmol) of the Intermediate 83 and 794 mg (2.52 mmol) of tetrabutylammonium fluoride trihydrate in 30 ml of anhydrous THF are stirred at room temperature overnight. The solution is concentrated and the residue is partitioned in ethyl acetate/water. The organic layer is washed with water, dried and concentrated. The residue is chromatographied on silicagel using dichloromethane/methanol 90:3 as eluent to give 590 mg (990% yield) of the desired compound as a yellowish oil.

Provenance & Evidence