((2-Chloroethyl)sulphonyl)benzene → HCID 67134364, compound

HRID 1925531Notes

Reaction equation

HRID 1925531 reaction equation
[CH3:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl[CH2:12][CH2:13][S:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=[O:16])=[O:15]>>[C:17]1([S:14]([CH2:13][CH2:12][CH2:1][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])(=[O:16])=[O:15])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 13646((2-Chloroethyl)sulphonyl)benzeneHCID 6433732-Methylnicotinic acid

Product 1

HCID 67134364HCID 67134364, compoundYield 16%

Procedure

Starting from 2.1 g (15.0 mmol) of 2-methyl-nicotinic acid and 4.6 g (22.5 mmol) of (2-chloroethyl)-phenylsulfone, 0.7 g (2.4 mmol, 16%) of 2-(3-(phenylsulfonyl)propyl)-nicotinic acid was obtained according to the process described in precursor VB006.

Sources & evidence

ORD record
ord-0e9610856f0f4962a3d5f92682ecf3f0
Source dataset
uspto-grants-2012_05
Patent number
US08178684B2

Reaction notes

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