Hydroxyamine hydrochloride → HCID 86656076, compound

Participants

Reaction Steps

In a 100 ml round-bottomed flask, a mixture of 231 mg of 5-quinolin-3-ylpyrrolo[1,2-a]indol-9-one obtained according to the preceding stage and 164 mg of hydroxylamine hydrochloride in 20 ml of pyridine is refluxed under argon. After heating for 1.5 hours, the reaction medium is evaporated to dryness under vacuum. The residue is taken up in a saturated solution of sodium bicarbonate and extracted twice with ethyl acetate. The combined organic phases are washed with a saturated solution of sodium bicarbonate and then a saturated solution of sodium chloride, dried over magnesium sulphate, and evaporated to dryness under vacuum. The residue is chromatographed on silica gel (15-40 μm), elution being carried out with a gradient of methanol (2% to 3% v/v) in dichloromethane. 277 mg of 5-quinolin-3-ylpyrrolo[1,2-a]indol-9-one oxime hydrochloride are obtained in the form of a yellowish solid, the characteristics of which are the following:

Provenance & Evidence