Ethanol → HCID 67299291, compound

Participants

Reaction Steps

In a 100 ml round-bottomed flask, a mixture of 277 mg of 5-quinolin-3-ylpyrrolo[1,2-a]indol-9-one oxime hydrochloride obtained according to the preceding stage, in 5 ml of acetic acid, 5 ml of ethanol and 5 ml of water, is stirred at ambient temperature. 58 mg of powdered zinc are added and the resulting mixture is left to stir for 1.5 hours. A further 58 mg of powdered zinc is added and the resulting mixture is left to stir for 3.5 hours. The reaction medium is filtered through clarcel, washing being carried out with 100 ml of methanol. The filtrate is evaporated to dryness under vacuum and chromatographed on silica gel (15-40 μm), elution being carried out with a gradient of methanol (2% to 7% v/v) in dichloromethane. 116 mg of 5-quinolin-3-yl-9H-pyrrolo[1,2-a]indol-9-ylamine acetate are obtained in the form of a brown solid, the characteristics of which are the following:

Provenance & Evidence