反应详情

温度

200 °C

In a 20 ml microwave reactor, a mixture of 256 mg of 9-oxo-9H-pyrrolo[1,2-a]indole-5-carboxylic acid (4-aminopyridin-3-yl)amide obtained according to the preceding stage, in 20 ml of glacial acetic acid, is heated at 200° C. for 30 minutes. The reaction medium is filtered through clarcel, washing being carried out with glacial acetic acid. The filtrate is evaporated to dryness under vacuum and the residue is taken up twice with toluene and each time re-evaporated to dryness under vacuum. The solid is triturated from isopropyl ether, filtered, and dried under vacuum at 40° C. overnight. 111 mg of 5-(3H-imidazo[4,5-c]pyridin-2-yl)pyrrolo[1,2-a]indol-9-one are obtained in the form of a solid, the characteristics of which are the following:

1. customobtained
2. filtrationThe reaction medium is filtered through clarcel
3. washwashing
4. customThe filtrate is evaporated to dryness under vacuum
5. customeach time re-evaporated to dryness under vacuum
6. customThe solid is triturated from isopropyl ether
7. filtrationfiltered
8. customdried under vacuum at 40° C. overnight