HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-2-(methylamino)propanoic acid → N-{[3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-N-methyl-D-alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-2-(methylamino)propanoic acid | HCID 92973 | — |
| Reactant | 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoic acid | HCID 25180783 | — |
| Reactant | N-{[3-(4-{[4-[5-Fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-N-methyl-L-alanine | HCID 57672635 | — |
| Product | N-{[3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-N-methyl-D-alanine | HCID 57672636 | — |
Reaction Steps
Prepared similarly to Intermediate 4 from 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoic acid and N-methyl-D-alanine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178573B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-28017332bac84ee2868ca8d10f91c0d4 |
| Source note | uspto-grants-2012_05 |