HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-aminopropanamide hydrochloride → N-[(1S)-2-Amino-1-methyl-2-oxoethyl]-3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-aminopropanamide hydrochloride | HCID 2775816 | — |
| Reactant | 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoic acid | HCID 25180783 | — |
| Product | N-[(1S)-2-Amino-1-methyl-2-oxoethyl]-3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzamide | HCID 24782160 | — |
Reaction Steps
Prepared similarly to Example 1 from 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoic acid and L-alaninamide hydrochloride with System A used for purification by mass directed autopreparation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178573B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-020d1e099cb349639d7cf9fb944c183b |
| Source note | uspto-grants-2012_05 |