HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1925611Generated: November 1, 2026
Sulfuric Acid → 3-Cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoic acid
https://huagongshe.com/reaction/1925611
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 3-Fluoro-2-methyl-4-(methylsulfonyl)benzoic acid | HCID 14254479 | — |
| Product | 3-Cyclopropylamino-2-methyl-4-(methylsulfonyl)benzoic acid | HCID 57424945 | — |
Reaction Steps
5.0 g (22 mmol) of 3-fluoro-2-methyl-4-(methylsulfonyl)benzoic acid were dissolved in 25.0 ml (356 mmol) of cyclopropylamine. The mixture was heated at 120° C. with stirring in an autoclave for 1 day, cooled to room temperature (RT), added to ice and conc. sulfuric acid and extracted with ethyl acetate. The combined organic phases were dried over MgSO4, and the solvent was removed under reduced pressure. The residue was purified by preparative HPLC. This gave 1.8 g of a beige solid in a purity of 95%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08178695B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-e1d839bdf293477d8f4cae4b771768b2 |
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| Source note | uspto-grants-2012_05 |
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