HRID1925647

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)C(=O)CC(C(=O)c1ccc(F)cc1)c1ccccc1

HCID14757173

1-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dione

C19H19FO2

结构：COc1ccc(B2O[C@H](CCN)C[C@H](CC(=O)OC(C)(C)C)O2)cc1

HCID66842096

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(B2O[C@H](CCn3c(C(C)C)cc(-c4ccccc4)c3-c3ccc(F)cc3)C[C@H](CC(=O)OC(C)(C)C)O2)cc1

HCID66842081

未命名化合物

PROCEDURE

实验过程

According to the same method as in Example 4-1, the title compound was synthesized using 1-(4-fluorophenyl)-5-methyl-2-phenyl-1,4-hexanedione and t-butyl 2-((4R,6R)-6-(2-aminoethyl)-2-(4-methoxyphenyl)-1,3,2-dioxaborinan-4-yl)acetate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4036a6e94525498eab6fe185a8643e1e
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08178697B2
来源说明: uspto-grants-2012_05

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][C:11](=O)[CH:12]([CH3:14])[CH3:13])=[CH:4][CH:3]=1.[NH2:23][CH2:24][CH2:25][C@H:26]1[O:31][B:30]([C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=2)[O:29][C@@H:28]([CH2:40][C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:27]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:23]([CH2:24][CH2:25][C@H:26]3[O:31][B:30]([C:32]4[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=4)[O:29][C@@H:28]([CH2:40][C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:27]3)[C:11]([CH:12]([CH3:14])[CH3:13])=[CH:10][C:9]=2[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:4][CH:3]=1