1-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dione → HCID 66841832, compound

HRID 1925658Notes

Reaction equation

HRID 1925658 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][C:11](=O)[CH:12]([CH3:14])[CH3:13])=[CH:4][CH:3]=1.[NH2:23][CH2:24][CH2:25][C@H:26]1[O:31][C:30]([CH3:33])([CH3:32])[O:29][C@@H:28]([CH2:34][C:35]([N:37]([CH:44]2[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]2)[CH:38]2[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]2)=[O:36])[CH2:27]1>>[CH:44]1([N:37]([CH:38]2[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]2)[C:35](=[O:36])[CH2:34][C@H:28]2[CH2:27][C@@H:26]([CH2:25][CH2:24][N:23]3[C:11]([CH:12]([CH3:14])[CH3:13])=[CH:10][C:9]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)=[C:8]3[C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[O:31][C:30]([CH3:33])([CH3:32])[O:29]2)[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49]1

Participants

3

Reactant 2

HCID 147571731-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dioneHCID 66842247HCID 66842247, compound

Product 1

HCID 66841832HCID 66841832, compound

Procedure

According to the same method as in Example 4-1, the tiotle compound was synthesized using 1-(4-fluorophenyl)-5-methyl-2-phenyl-1,4-hexanedione and 2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dicyclohexylacetamide.

Workup

  1. customthe tiotle compound was synthesized

Sources & evidence

ORD record
ord-64ae2f75dd324a29b6800b72621b1f65
Source dataset
uspto-grants-2012_05
Patent number
US08178697B2

Reaction notes

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