1-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dione → HCID 66842504, compound

HRID 1925660Notes

Reaction equation

HRID 1925660 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH:9]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:10][C:11](=O)[CH:12]([CH3:14])[CH3:13])=[CH:4][CH:3]=1.[NH2:23][CH2:24][CH2:25][C@H:26]1[O:31][C:30]2([CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)[O:29][C@@H:28]([CH2:37][C:38]([N:40]2[CH2:45][CH2:44][O:43][CH2:42][CH2:41]2)=[O:39])[CH2:27]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:23]([CH2:24][CH2:25][C@H:26]3[O:31][C:30]4([CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]4)[O:29][C@@H:28]([CH2:37][C:38]([N:40]4[CH2:45][CH2:44][O:43][CH2:42][CH2:41]4)=[O:39])[CH2:27]3)[C:11]([CH:12]([CH3:14])[CH3:13])=[CH:10][C:9]=2[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 147571731-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dioneHCID 66842216HCID 66842216, compound

Product 1

HCID 66842504HCID 66842504, compound

Procedure

According to the same method as in Example 4-1, the title compound was synthesized using 1-(4-fluorophenyl)-5-methyl-2-phenyl-1,4-hexanedione and 2-((2R,4R)-4-(2-aminoethyl)-1,5-dioxaspiro[5.5]undecan-2-yl)-1-morpholinoethanone.

Sources & evidence

ORD record
ord-4ba1566fc76747f0a4031b32314008c0
Source dataset
uspto-grants-2012_05
Patent number
US08178697B2

Reaction notes

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