Methanol → Atorvastatin Calcium

Participants

Reaction Conditions

Reaction Steps

In a reactor, 213 g of the atorvastatin sodium salt, obtained in Example 6, was mixed with 1.0 L of methanol and 6.0 L of purified water, and the solution was then heated to 50° C. Then, the heated solution was slowly added dropwise to a solution of 0.5 molar equivalents of calcium acetate in 0.6 L of water in another reactor. After the completion of the addition, the mixture was slowly cooled to 15° C. with stirring for 2 hours, and then was filtered. The resulting solid was washed with 2 L of purified water, and then dried in a vacuum at 50° C., thus obtaining 205 g of atorvastatin hemicalcium salt.

Provenance & Evidence