Hydrochloric Acid → HCID 25183370, compound

Participants

Reaction Steps

To a solution of 11 (24.7 mL; 0.06 mmol) in tetrahydrofuran (5 mL) in a 2.5-5.0 mL microwave reactor tube was added aqueous lithium hydroxide (1 mL; 2M). The reaction vessel was subjected to the following microwave conditions: Temperature=140° C.; Time=15 minutes; Power=250 W; Cooling on; Absorption=Very High. The crude reaction mixture was allowed to cool to room temperature, acidified by the addition of aqueous hydrochloric acid (15 mL; 2N), and extracted with ethyl acetate (3×10 mL). The organic phases were combined and dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford a beige solid. The latter was triturated from diisopropyl ether to yield the title compound as a beige solid (24.1 mg).

Provenance & Evidence