Sodium Hydroxide → HCID 25183797, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 32 (0.25 g; 0.65 mmol) in tetrahydrofuran (15 mL) and methanol (5 mL) was added aqueous sodium hydroxide (10 mL; 2M). The reaction mixture was heated at 75-80° C. for 6 hours, allowed to cool to room temperature and then concentrated under reduced pressure. The resulting residue was dissolved in chloroform (15 mL) and washed with aqueous hydrochloric acid (2×10 mL, 2N). The organic phase was dried over magnesium sulfate, filtered, and concentrated under reduced pressure to yield the title compound as a white solid (188 mg).

Provenance & Evidence