Sodium Hydroxide → HCID 25183366, compound

Participants

Reaction Steps

To a solution of 64 (210 mg; 0.14 mmol) in methanol (2 mL) was added aqueous sodium hydroxide (2 mL; 2N) and the resulting mixture was stirred overnight at room temperature. The solvent was removed under reduced pressure and the resulting residue was dissolved in water, acidified to pH 2 with aqueous hydrochloric acid (2N), and extracted with ethyl acetate. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The desired product was obtained from dichloromethane and hexanes as a yellow solid (75 mg).

Provenance & Evidence