Tetralin → 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride

HRID 1925718Notes

Reaction equation

HRID 1925718 reaction equation
[CH:1]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[Cl:11][S:12](O)(=[O:14])=[O:13]>ClCCl>[CH:9]1[C:10]2[CH2:1][CH2:2][CH2:3][CH2:4][C:5]=2[CH:6]=[CH:7][C:8]=1[S:12]([Cl:11])(=[O:14])=[O:13]

Participants

4

Reactant 2

HCID 8404TetralinHCID 24638Chlorosulfonic acid

Product 1

HCID 48683715,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of commercially available 5,6,7,8-tetrahydronaphthalene (1.45 g; 11.3 mmol) in dichloromethane (22.7 mL) cooled to 0° C. was added chlorosulfonic acid (0.9 mL; 13.5 mmol) fast dropwise. The reaction mixture was stirred overnight warming to room temperature gradually. The reaction mixture was used in the next reaction directly without purification.

Workup

  1. customThe reaction mixture was used in the next reaction directly without purification

Sources & evidence

ORD record
ord-5513d97b67ef4b5d9e62a2358e6fd01a
Source dataset
uspto-grants-2012_05
Patent number
US08178699B2

Reaction notes

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