HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → Methyl 3-(5,6,7,8-tetrahydronaphthalene-2-sulfonamido)thiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Methyl 3-amino-2-thiophenecarboxylate | HCID 89652 | — |
| Reactant | 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride | HCID 4868371 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 3-(5,6,7,8-tetrahydronaphthalene-2-sulfonamido)thiophene-2-carboxylate | HCID 8823208 | 31.3% |
Reaction Steps
Synthesized as described for 52 except using a solution of 77 (1.30 g; 5.64 mmol) in anhydrous dichloromethane (11 mL), methyl 3-aminothiophene-2-carboxylate (892 mg; 5.67 mmol), pyridine (1.14 mL; 14.10 mmol) and anhydrous dichloromethane (11 mL). This afforded the desired product as yellow solid (0.62 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178699B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-3ed117ef37434f2ca9d8a2ae97e2e041 |
| Source note | uspto-grants-2012_05 |