Bicarbonate Ion → 2-(Chloromethyl)-N-[6-{6-(methyloxy)-5-[(methylsulfonyl)amino]-3-pyridinyl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-thiazole-4-carboxamide
Reaction equation
[C:49](=[O:50])([OH:51])[O-:52].[Cl:39][CH2:40][c:41]1[s:42][cH:43][c:44]([C:46](=[O:47])[Cl:48])[n:45]1.[Cl:54][CH2:55][Cl:56].[NH2:1][c:2]1[c:3]2[cH:4][n:5][n:6]([S:24](=[O:25])(=[O:26])[c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)[c:7]2[cH:8][c:9](-[c:11]2[cH:12][c:13]([NH:19][S:20](=[O:21])(=[O:22])[CH3:23])[c:14]([O:17][CH3:18])[n:15][cH:16]2)[cH:10]1.[Na+:53].[cH:33]1[cH:34][cH:35][n:36][cH:37][cH:38]1>>[NH:1]([c:2]1[c:3]2[cH:4][n:5][n:6]([S:24](=[O:25])(=[O:26])[c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)[c:7]2[cH:8][c:9](-[c:11]2[cH:12][c:13]([NH:19][S:20](=[O:21])(=[O:22])[CH3:23])[c:14]([O:17][CH3:18])[n:15][cH:16]2)[cH:10]1)[C:46]([c:44]1[cH:43][s:42][c:41]([CH2:40][Cl:39])[n:45]1)=[O:47]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-b6f5daddb353453382f735bfdfe367a5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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