Chlorosulfonic acid → HCID 59180449, compound

HRID 1925735Notes

Reaction equation

HRID 1925735 reaction equation
Cl[S:2]([OH:5])(=[O:4])=[O:3].[C:6]([C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1S(O)(=O)=O)([CH3:9])([CH3:8])[CH3:7]>ClCCl>[C:6]([C:10]1[CH:11]=[CH:12][C:13]([S:2]([OH:5])(=[O:4])=[O:3])=[C:14]([F:16])[CH:15]=1)([CH3:9])([CH3:7])[CH3:8]

Participants

4

Reactant 2

HCID 24638Chlorosulfonic acidHCID 86638763HCID 86638763, compound

Product 1

HCID 59180449HCID 59180449, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Synthesized as described for 1 using 106 (830.0 mg; 5.45 mmol), chlorosulfonic acid (0.44 mL; 6.54 mmol) and anhydrous dichloromethane (25 mL). The crude gray solid obtained was washed with hexanes and dried under reduced pressure. This afforded a 3:1 regioisomeric mixture of the title compound and 2-tert-butyl-4-fluorobenzenesulfonic acid (960 mg).

Workup

  1. customSynthesized
  2. customThe crude gray solid obtained
  3. washwas washed with hexanes
  4. customdried under reduced pressure
  5. customThis afforded

Sources & evidence

ORD record
ord-8f0490224921402999be4ed2128cd342
Source dataset
uspto-grants-2012_05
Patent number
US08178699B2

Reaction notes

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