HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → Methyl 3-[4-(n-butyl)phenylsulfonamido]thiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Methyl 3-amino-2-thiophenecarboxylate | HCID 89652 | — |
| Reactant | 4-Butylbenzene-1-sulfonyl chloride | HCID 2737352 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 3-[4-(n-butyl)phenylsulfonamido]thiophene-2-carboxylate | HCID 19683024 | — |
Reaction Steps
Synthesized as described for 52 using commercially available 4-n-butylbenzenesulfonyl chloride (0.47 g; 2 mmol), methyl 3-aminothiophene-2-carboxylate (314 mg; 2 mmol), pyridine (0.2 mL; 2.4 mmol), and anhydrous dichloromethane (10 mL). This afforded the title compound as a clear oil which later solidified (0.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178699B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-17079c60b89c455b89382157e6a937d6 |
| Source note | uspto-grants-2012_05 |